Sermorelin
Overview
Sermorelin is a synthetic analogue of the first 29 amino acids of endogenous GHRH. It was previously FDA-approved as a diagnostic agent for GH deficiency and as a treatment in children. It stimulates the pituitary gland to produce its own GH rather than introducing exogenous GH directly.
How it works
Binds to GHRH receptors on anterior pituitary somatotrophs, stimulating the natural pulsatile synthesis and release of growth hormone. Works within the body's own feedback mechanisms, reducing the risk of GH excess. The resulting GH release then stimulates IGF-1 production in the liver.
Primary uses
- Growth hormone stimulation
- Anti-ageing
- Muscle growth
- Fat loss
- Sleep quality improvement
- Bone density
What to expect
Based on reported user experiences and available research, here is a general timeline of effects:
Days 1–14
- Natural pulsatile GH release begins increasing from the first dose
- Sleep quality and depth often improve within the first week
- Take before bed on an empty stomach for optimal GH pulse
Days 14–56
- IGF-1 levels are building measurably by week 4
- Body composition and recovery improvements are emerging
- Skin quality improvements are often noticed around week 4-6
Days 56–999
- Anti-ageing, recovery, and body composition benefits well established
- Works within your body's own feedback mechanisms — lower side effect risk than exogenous GH
- Long-term bone density support is accumulating
Storage and preparation
Store lyophilised at -20°C long term or 4°C short term. Once reconstituted, refrigerate and use within 14 days. Sensitive to heat — keep cold.
Reconstitute with bacteriostatic water. Common: 15mg vial with 15ml BAC water gives 1000mcg/ml. For 300mcg dose, draw 0.3ml. Inject immediately before bed on an empty stomach for optimal GH pulse.
Research
The following studies are available via PubMed:
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