Ipamorelin
Overview
Ipamorelin is a selective growth hormone secretagogue and GHRP (Growth Hormone Releasing Peptide). It is considered one of the cleanest GHRPs available due to its highly selective action — stimulating GH release without significantly raising cortisol or prolactin. Commonly stacked with CJC-1295.
How it works
Acts as a selective agonist at the ghrelin receptor (GHS-R1a) on pituitary somatotrophs, triggering pulsatile GH release. Unlike other GHRPs, Ipamorelin does not significantly stimulate ACTH, cortisol, aldosterone, or prolactin, making it highly selective for GH secretion.
Primary uses
- Growth hormone stimulation
- Muscle growth
- Fat loss
- Sleep quality
- Recovery
- Anti-ageing
What to expect
Based on reported user experiences and available research, here is a general timeline of effects:
Days 1–14
- Selective GH release begins with first dose — minimal cortisol or prolactin impact
- Sleep quality often improves within the first week
- Appetite may increase slightly as GH levels rise
Days 14–56
- IGF-1 levels are building — muscle preservation and recovery benefits emerging
- Fat metabolism is improving with elevated GH signalling
- Recovery between sessions is typically faster by week 3-4
Days 56–999
- Body composition improvements are well established at 2+ months
- Anti-ageing effects on skin and connective tissue are accumulating
- Consider stacking with CJC-1295 for amplified GH pulse effect
Storage and preparation
Store lyophilised at -20°C. Once reconstituted, store at 4°C and use within 30 days. Protect from light.
Reconstitute with bacteriostatic water. Common: 5mg vial with 2.5ml BAC water gives 2000mcg/ml. For 200mcg dose, draw 0.1ml.
Research
The following studies are available via PubMed:
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